Protease-Activated Receptor-1, PAR-1 Agonist;
Protease-Activated Receptor-1, PAR-1 Agonist 是一种选择性蛋白酶激活受体1 (PAR-1) 激动肽。Protease-Activated Receptor-1, PAR-1 Agonist 对应于PAR1配体，可通过该受体选择性地模拟凝血酶的作用。
Protease-Activated Receptor-1, PAR-1 Agonist Chemical Structure
CAS No. : 141136-85-8
| 规格 | 是否有货 | ||
|---|---|---|---|
| 100 mg | ; | 询价 | ; |
| 250 mg | ; | 询价 | ; |
| 500 mg | ; | 询价 | ; |
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Protease-Activated Receptor-1, PAR-1 Agonist 的其他形式现货产品:
| 生物活性 |
Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor[1][2]. |
IC50 Target |
PAR-1[1] |
|---|---|
| 体外研究 (In Vitro) |
Protease-Activated Receptor-1, PAR-1 Agonist induces activation of protein kinase C isoenzymes alpha and epsilon in human HT-29 colon carcinoma cells expressing PAR1 endogeneously. On the cellular level, Protease-Activated Receptor-1, PAR-1 Agonist and thrombin prompted HT-29 cell migration and matrix adhesion by a PKCepsilon-dependent mechanism as concluded because of the inhibition of PAR1-mediated effects by the PKC inhibitor bisindolylmaleimide I and the PKCepsilon translocation inhibitory peptide EAVSLKPT but not by the PKC inhibitor Gö 6976[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
762.90 |
| Formula |
C35H58N10O9 |
| CAS 号 |
141136-85-8 |
| Sequence |
Thr-Phe-Leu-Leu-Arg-Asn |
| Sequence Shortening |
TFLLRN |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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