Cyclic MKEY TFA

发表于由

Cyclic MKEY TFA;

Cyclic MKEY TFA 是 CXCL4-CCL5 异二聚体形成的合成环肽抑制剂，其通过介导炎症来防止动脉粥样硬化和主动脉瘤形成。Cyclic MKEY TFA 还可以预防小鼠中风引起的脑损伤。

Cyclic MKEY TFAamp;;

Cyclic MKEY TFA Chemical Structure

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生物活性

Cyclic MKEY TFA is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY TFA also protects against stroke-induced brain injury in mice[1][2].

IC50 Target

CXCL4-CCL5[1]
分子量

2646.91

Formula

C115H175N28F3O36S2
Sequence Shortening

CKEYFYTSSKSSNLAVVFVTRC
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Fan Y,et al. MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice. J Am Heart Assoc. 2016 Sep 15;5(9). pii: e003615.

    [2]. Iida Y, et al. Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):718-26.