F1324 TFA

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F1324 TFA;

F1324 TFA 是一种有效、高亲和力的 BCL6 多肽抑制剂，IC50 值为 1 nM。F1324 TFA 结合 BCL6 动力学 t1/2 为 441 s, 对 BCL6 PPI 具有很强的抑制作用。

F1324 TFAamp;;

F1324 TFA Chemical Structure

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生物活性

F1324 TFA is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM. F1324 TFA exhibits binding t1/2 value of 441 s and has strong inhibition activity against BCL6 PPI[1].

IC50 Target

IC50: 1 nM (BCL6)[1]
体外研究
(In Vitro)

F1324 TFA binds to BCL6(5-129) with KD and IC50 values of 0.57 nM and 1 nM according to the results of an SPR analysis and cell-free ELISA assay, respectively[1].
F1324 TFA binds BCL6 not only in cell-free but also cellbased conditions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1879.06

Formula

C85H122N21F3O22S
Sequence Shortening

Ac-LWYTDIRMSWRVP-OH
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sakamoto K, et al. Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship. Biochem Biophys Res Commun. 2017 Jan 8;482(2):310-316.