Nociceptin (1-13), amide

发表于由

Nociceptin (1-13), amide;

Nociceptin (1-13), amide 是一种有效的阿片受体 ORL1 (OP4) 受体激动剂，对小鼠输精管 pEC50 值为 7.9，与大鼠前脑膜结合的 Ki 值为 0.75 nM。

Nociceptin (1-13), amideamp;;

Nociceptin (1-13), amide Chemical Structure

CAS No. : 178064-02-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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Nociceptin (1-13), amide 的其他形式现货产品:

Nociceptin (1-13), amide TFA

生物活性

Nociceptin (1-13), amide is a potent ORL1 receptor (opioid receptor-like 1 receptor, OP4) agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes[1][2].

IC50 Target

Ki: 0.75 nM (binding to rat forebrain membranes)[1]
pEC50: 7.9 (in mouse vas deferens)[2]
体内研究
(In Vivo)

ORL1受体激动剂

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1381.59

Formula

C61H100N22O15
CAS 号

178064-02-3
Sequence Shortening

FGGFTGARKSARK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Varani K, et al. Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br J Pharmacol. 1998 Dec;125(7):1485-90.

    [2]. Calo’ G, et al. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol. 2000 Apr;129(7):1261-83.