Substance P (7-11);
Substance P (7-11) 是神经肽物质P的C-末端片段,其可引起细胞内钙浓度的增加。
![Substance P (7-11) Chemical Structure Substance P (7-11)amp;;](http://file.medchemexpress.cn/product_pic/hy-p1492.gif)
Substance P (7-11) Chemical Structure
CAS No. : 51165-05-0
规格 | 价格 | 是否有货 | |
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5 mg | ¥950 | 询问价格 货期 | |
10 mg | ¥1600 | 询问价格 货期 | |
25 mg | ¥3300 | 询问价格 货期 |
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生物活性 |
Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration. |
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体外研究 (In Vitro) |
Substance P (7-11) increases PGE2 and collagenase production at concentrations greater than 1 μM. Substance P (7-11), but not intact SP, SP-(1-4), SP-(1-6), SP- (8-11) or SP-(9-1 1), nor the tachykinins NKA and NKB, causes an increase in the intracellular calcium concentration as measured by the fluorescent dye Fura-2. The maximal change in intracellular calcium induced by 10 μM Substance P (7-11) was 140±30 nM[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
612.78 |
Formula |
C31H44N6O5S |
CAS 号 |
51165-05-0 |
Sequence |
Phe-Phe-Gly-Leu-Met-NH2 |
Sequence Shortening |
FFGLM-NH2 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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Cell Assay [1] |
Confluent chondrocytes are incubated for 24 h with SP or Substance P (7-11). TIMP activity is inactivated following reduction and alkylation with 2 mM dithiothreitol and 5 mM iodoacetamide for 30 min at 37°C. Samples are subsequently dialysed. Latent collagenase is activated with 1 mM APt followed by inactivation with soy bean trypsin inhibitor. Collagenase is measured[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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