C3a (70-77);(Synonyms: Complement 3a (70-77))
C3a (70-77) 是对应于C3a的COOH末端的八肽,表现出C3a的特异性和1至2%的生物活性。
C3a (70-77) Chemical Structure
CAS No. : 63555-63-5
规格 | 是否有货 | ||
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100 mg | ; | 询价 | ; |
250 mg | ; | 询价 | ; |
500 mg | ; | 询价 | ; |
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C3a (70-77) 的其他形式现货产品:
生物活性 |
C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a. |
IC50 Target |
Complement system[1] |
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体外研究 (In Vitro) |
The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD. The extent of suppression of LIF generation by C3a(70-77) is significant at concentrations of 10-7 M or higher and exceeds 75% at 10-6 M, irrespective of the stimulus[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
823.94 |
Formula |
C35H61N13O10 |
CAS 号 |
63555-63-5 |
Sequence |
Ala-Ser-His-Leu-Gly-Leu-Ala-Arg |
Sequence Shortening |
ASHLGLAR |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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Kinase Assay [1] |
2×105 mononuelear leukocytes in 0.2 mL of M199-HPS containing 15% (vol/vol) AB-positive serum are added to each well of microtiter plates without or with 10 μg/mL of Con A, PHA, or SK-SD and incubated at 37°C in 5% CO2:95% air. C3a or C3a(70-77) is introduced into some suspensions at the same time as the stimulus or buffer. After 3 d for the mitogen-stimulated cultures and 5 d for the SK-SD-stimulated cultures, 1 μCi of [3H]thymidine is added to each well. After an additional 16 h at 37°C, the uptake of [3H]thymidine is analyzed by aspirating the contents of each well with a Mash II harvester that collected and ished the leukocytes on glass fiber filters. The radioactivity in each filter is quantified, and the results for quadruplicate chambers are expressed as mean cpm+SEM[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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