Thymus factor X(Synonyms: 胸腺因子X TFX-Jelfa) | Cytiva思拓凡-Whatman滤纸滤膜滤器

Thymus factor X;(Synonyms: 胸腺因子X; TFX-Jelfa) 纯度: ge;98.0%

Thymic factor X (TFX-Jelfa) 是一种来自幼年小牛胸腺的水提取物，也是一种天然的淋巴细胞功能刺激剂。

Thymus factor Xamp;;(Synonyms: 胸腺因子X; TFX-Jelfa)

Thymus factor X Chemical Structure

CAS No. : 78310-77-7

规格	价格	是否有货	数量
1 mg	￥1800	In-stock
5 mg	￥7200	In-stock
10 mg	;	询价	;
50 mg	;	询价	;

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Thymus factor X 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Peptide Library

生物活性

Thymic factor X (TFX-Jelfa) is an aqueous extract from juvenile calf thymuses and a natural stimulator of lymphocyte function^[1]^[2].

体内研究
(In Vivo)

The percentage of necrotic lymphocytes in the spleen in Group I (infected with T. spiralis and treated with Thymus factor X (TFX)) is significantly lower than in the control group on day 7, and approximately the same as in the control group for the rest of the experiment. The percentage of necrotic lymphocytes in muscle tissue in Group I is approximately the same as in the control group on day 7, significantly lower on days 14 and 21 (p<0.0002), approximately the same on days 28 and 35, significantly lower on day 42, and significantly higher on day 60 (p<0.005)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS 号

78310-77-7

中文名称

胸腺因子X

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Piekarska J, et al. Trichinella spiralis: Effect of thymus factor X on apoptosis and necrosis in mice. Exp Parasitol. 2009 Oct;123(2):128-33.

[2]. Skotnicki AB. Therapeutic application of calf thymus extract (TFX). Med Oncol Tumor Pharmacother. 1989;6(1):31-43.

Animal Administration ^[1]	The experiment is carried out using 134 mice divided into three groups: Group I: 46 mice infected with T. spiralis and treated with Thymus factor X (TFX); Group II: 42 uninfected mice treated with Thymus factor X; and Control group: 46 mice infected with T. spiralis and not treated with Thymus factor X. Thymus factor X is administered subcutaneously at a dose of 15 mg/kg. The first dose is administered on the third day before the mice are infected with T. spiralis. The dose is repeated at 24 h intervals until the thirteenth day after infection. In all, 17 doses are administered. On days 7, 14, 21, 28, 35, 42, and 60 after infection, six mice from each group are sacrificed using halothane. The spleen, mesenteric lymph nodes and masseter muscles are excised from each mouse and transferred to sterile phospho-buffered saline at 4°C^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Piekarska J, et al. Trichinella spiralis: Effect of thymus factor X on apoptosis and necrosis in mice. Exp Parasitol. 2009 Oct;123(2):128-33. [2]. Skotnicki AB. Therapeutic application of calf thymus extract (TFX). Med Oncol Tumor Pharmacother. 1989;6(1):31-43.

Animal Administration
^[1]

The experiment is carried out using 134 mice divided into three groups: Group I: 46 mice infected with T. spiralis and treated with Thymus factor X (TFX); Group II: 42 uninfected mice treated with Thymus factor X; and Control group: 46 mice infected with T. spiralis and not treated with Thymus factor X. Thymus factor X is administered subcutaneously at a dose of 15 mg/kg. The first dose is administered on the third day before the mice are infected with T. spiralis. The dose is repeated at 24 h intervals until the thirteenth day after infection. In all, 17 doses are administered. On days 7, 14, 21, 28, 35, 42, and 60 after infection, six mice from each group are sacrificed using halothane. The spleen, mesenteric lymph nodes and masseter muscles are excised from each mouse and transferred to sterile phospho-buffered saline at 4°C^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Piekarska J, et al. Trichinella spiralis: Effect of thymus factor X on apoptosis and necrosis in mice. Exp Parasitol. 2009 Oct;123(2):128-33.

[2]. Skotnicki AB. Therapeutic application of calf thymus extract (TFX). Med Oncol Tumor Pharmacother. 1989;6(1):31-43.