Hexa-D-arginine(Synonyms: Furin Inhibitor II)

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Hexa-D-arginine;(Synonyms: Furin Inhibitor II) 纯度: 99.57%

Hexa-D-arginine (Furin Inhibitor II) 是一种稳定的 furin 抑制剂，对 furin，PACE4 和 PC1 的 Ki 值分别为 106 nM，580 nM 和 13.2 μM。Hexa-D-arginine 在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。

Hexa-D-arginineamp;;(Synonyms: Furin Inhibitor II)

Hexa-D-arginine Chemical Structure

CAS No. : 673202-67-0

规格 价格 是否有货 数量
1 mg ￥950 In-stock
5 mg ￥3800 In-stock
10 mg ￥6800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Hexa-D-arginine 相关产品

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  • Peptide Library

生物活性

Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3].

IC50 Target

Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)[3]
体外研究
(In Vitro)

Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

954.14

Formula

C36H75N25O6
CAS 号

673202-67-0
Sequence Shortening

RRRRRR-NH2
中文名称

六-D-精氨酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 50 mg/mL (52.40 mM; Need ultrasonic)

DMSO : 5 mg/mL (5.24 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0481 mL 5.2403 mL 10.4806 mL
5 mM 0.2096 mL 1.0481 mL 2.0961 mL
10 mM 0.1048 mL 0.5240 mL 1.0481 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9.

    [2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5.

    [3]. Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9.