Etelcalcetide hydrochloride(Synonyms: AMG 416 hydrochloride KAI-4169 hydrochloride)

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Etelcalcetide hydrochloride;(Synonyms: AMG 416 hydrochloride; KAI-4169 hydrochloride) 纯度: 99.31%

Etelcalcetide hydrochloride (AMG 416 hydrochloride) 是一种合成肽，有钙敏感受体 (CaSR) 活化剂的作用。Etelcalcetide hydrochloride 可有效降低接受血液透析的继发性甲状旁腺功能亢进患者的甲状旁腺激素 (PTH) 浓度。

Etelcalcetide hydrochlorideamp;;(Synonyms: AMG 416 hydrochloride; KAI-4169 hydrochloride)

Etelcalcetide hydrochloride Chemical Structure

CAS No. : 1334237-71-6

规格 价格 是否有货 数量
1 mg ￥550 In-stock
5 mg ￥2000 In-stock
10 mg ￥3400 In-stock
25 mg ￥6800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Etelcalcetide hydrochloride 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis[1].

Clinical Trial

分子量

1353.33

Formula

C38H74ClN21O10S2
CAS 号

1334237-71-6
Sequence Shortening

C1′ . Ac-{d-Cys1}-{d-Ala}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Ala}-{d-Arg}-NH2 (Disulfide bridge: Cys1′-Cys1)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (73.89 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7389 mL 3.6946 mL 7.3892 mL
5 mM 0.1478 mL 0.7389 mL 1.4778 mL
10 mM 0.0739 mL 0.3695 mL 0.7389 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Block GA, et al. Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial. JAMA. 2017 Jan 10;317(2):156-164.