[Pyr1]-Apelin-13(Synonyms: [pGlu1]-Apelin-13)

发表于由

[Pyr1]-Apelin-13;(Synonyms: [pGlu1]-Apelin-13) 纯度: 98.76%

[Pyr1]-Apelin-13 是一种高效的，选择性的内源性 apelin 受体激动剂。

[Pyr1]-Apelin-13amp;;(Synonyms: [pGlu1]-Apelin-13)

[Pyr1]-Apelin-13 Chemical Structure

CAS No. : 217082-60-5

规格 价格 是否有货 数量
1 mg ￥1000 In-stock
5 mg ￥4000 In-stock
10 mg ￥7500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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[Pyr1]-Apelin-13 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Cardiovascular Disease Compound Library
  • Peptide Library

生物活性

[Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.

体外研究
(In Vitro)

[Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release under physiological conditions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

[Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction[1]. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1533.80

Formula

C69H108N22O16S
CAS 号

217082-60-5
Sequence Shortening

{Glp}-RPRLSHKGPMPF
中文名称

[Pyr1]-爱帕琳肽-13
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (65.20 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6520 mL 3.2599 mL 6.5198 mL
5 mM 0.1304 mL 0.6520 mL 1.3040 mL
10 mM 0.0652 mL 0.3260 mL 0.6520 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Serpooshan V, et al. [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction. Biomaterials. 2015 Jan;37:289-98.

    [2]. Hajimashhadi Z, et al. Chronic administration of [Pyr1] apelin-13 attenuates neuropathic pain after compression spinal cord injury in rats. Neuropeptides. 2017 Feb;61:15-22.