Gastric mucin;(Synonyms: 胃膜素)
Gastric mucin 是一种大的糖蛋白，保护胃肠道免受酸、蛋白酶、致病微生物和机械创伤的影响。
Gastric mucin Chemical Structure
CAS No. : 84082-64-4
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 500 mg | ￥400 | In-stock | |
| 1 g | ￥500 | In-stock | |
| 5 g | ; | 询价 | ; |
| 10 g | ; | 询价 | ; |
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Gastric mucin 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Peptide Library
| 生物活性 |
Gastric mucin is a large glycoprotein which is thought to play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma. In Vitro: Gastric mucin may be integrally involved in the mechanism of gastric mucosal injury caused by Helicobacter pylori leading to gastritis, peptic ulceration, and possibly gastric cancer[1]. Gastric mucins are classified into two types based on their histochemical properties. The first is a surface mucous cell-type mucin, secreted from the surface mucous cells. The second is found in deeper portions of the mucosa and is secreted by gland mucous cells, including mucous neck cells, cardiac gland cells, and pyloric gland cells. The unique O-glycans in gastric mucin appears to function as a natural antibiotic, protecting the host from H. pylori infection[2]. Gastric mucin may provide protection to the surface epithelium gastrointestinal tract by scavenging oxidants produced within the lumen; however, it does so at the expense of its viscoelastic properties. Both native and pronase-treated mucin effectively scavenge hydroxyl radical and that the scavenging properties are not significantly different. The effective concentration of mucin required for a 50% reduction in malondialdehyde production is 10 mg/mL for both native and pronase-treated mucin[3]. |
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| 体外研究 (In Vitro) |
Gastric mucin may be integrally involved in the mechanism of gastric mucosal injury caused by Helicobacter pylori leading to gastritis, peptic ulceration, and possibly gastric cancer[1]. Gastric mucins are classified into two types based on their histochemical properties. The first is a surface mucous cell-type mucin, secreted from the surface mucous cells. The second is found in deeper portions of the mucosa and is secreted by gland mucous cells, including mucous neck cells, cardiac gland cells, and pyloric gland cells. The unique O-glycans in gastric mucin appears to function as a natural antibiotic, protecting the host from H. pylori infection[2]. Gastric mucin may provide protection to the surface epithelium gastrointestinal tract by scavenging oxidants produced within the lumen; however, it does so at the expense of its viscoelastic properties. Both native and pronase-treated mucin effectively scavenge hydroxyl radical and that the scavenging properties are not significantly different. The effective concentration of mucin required for a 50% reduction in malondialdehyde production is 10 mg/mL for both native and pronase-treated mucin[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| CAS 号 |
84082-64-4 |
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| 中文名称 |
胃膜素；胃黏膜素 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:;
DMSO : < 1 mg/mL (insoluble or slightly soluble) 1M NaOH : < 1 mg/mL (insoluble) H2O : < 0.1 mg/mL (insoluble) |
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| 参考文献 |
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