Nattokinase

Nattokinase;

Nattokinase 是一种有效的纤溶酶,可通过直接水解纤维蛋白和纤溶酶底物来分解血凝块。Nattokinase 可用于研究心血管疾病。

Nattokinaseamp;;

Nattokinase Chemical Structure

CAS No. : 133876-92-3

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Nattokinase 相关产品

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  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Nattokinase is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases[1].

体外研究
(In Vitro)

Nattokinase dissolves 94% blood clot at ten minutes and degrades the fibrin clot after two hours of incubation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Nattokinase (150-250 mg/kg; oral gavage twice daily for 2 days) exhibits fibrinolytic activity and dissolves blood clots in vivo[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (SD) rats (180-220 g) are injected κ-Carrageenan[3]
Dosage: 150, 250 mg/kg
Administration: Oral gavage twice daily for 2 days
Result: Increased the plasma concentration of fibrin/fibrinogen degradation products (FDPs) and D-Dimer in a dose-dependent manner.
Decreased the fraction of the vessel cross section occupied by thrombosis.

Clinical Trial

CAS 号

133876-92-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (Need ultrasonic)

参考文献
  • [1]. Weng Y, et, al. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017 Feb 28; 18(3):523.

    [2]. Chandrasekaran SD, et, al. Exploring the In Vitro Thrombolytic Activity of Nattokinase From a New Strain Pseudomonas aeruginosa CMSS. Jundishapur J Microbiol. 2015 Oct 26; 8(10): e23567.

    [3]. Xu J, et, al. Thrombolytic effects in vivo of nattokinase in a carrageenan-induced rat model of thrombosis. Acta Haematol. 2014; 132(2): 247-53.