CYN 154806 TFA; 纯度: 99.81%
CYN 154806 TFA 是一种环状八肽，是一种强效的，选择性生长抑素 sst2 受体的拮抗剂，其对人重组 sst2、sst1、sst3、sst4 和 sst5 受体的 pIC50 值分别为 8.58、5.41、6.07、5.76 和 6.48。
CYN 154806 TFA Chemical Structure
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 1 mg | ￥1800 | In-stock | |
| 5 mg | ￥5800 | In-stock | |
| 10 mg | ￥9800 | In-stock | |
| 50 mg | ; | 询价 | ; |
| 100 mg | ; | 询价 | ; |
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CYN 154806 TFA 相关产品
bull;相关化合物库:
- Covalent Screening Library Plus
- Bioactive Compound Library Plus
- GPCR/G Protein Compound Library
- Neuronal Signaling Compound Library
- Covalent Screening Library
- Macrocyclic Compound Library
- Endocrinology Compound Library
- Targeted Diversity Library
- Peptide Library
| 生物活性 |
CYN 154806 TFA, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively[1][2]. |
IC50 Target |
Somatostatin Receptor[1] |
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| 体外研究 (In Vitro) |
CYN 154806 TFA inhibits SRIF-induced increases in extracellular acidification (EAR) in CHO-K1 cells expressing human sst2 receptors (pKB 7.92). CYN 154806 TFA also blocks SRIF-induced increases [35S]-GTPγS binding in CHO-K1 cell membranes expressing human sst2 receptors as well as rat sst2(a) and rat sst2(b) receptors (pKB 7.81, 7.68 and 7.96, respectively)[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 体内研究 (In Vivo) |
CYN 154806 TFA (0.1 mg/kg; i.p.; 20 min before the administration of carbachol (CCh) (30 μg/kg) in M4 KO mice) dose-dependently and significantly reverses the decreases acid response to CCh in M4 but not M3 KO mice[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
1311.36 |
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| Formula |
C58H69F3N12O16S2 |
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| Sequence |
Ac-Phe(4-NO2)-Cys-Tyr-Trp-Lys-Thr-Cys-Tyr-NH2 (Disulfide bridge: Cys2-Cys7) |
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| Sequence Shortening |
Ac-F(4-NO2)CYWKTCY-NH2 (Disulfide bridge: Cys2-Cys7) |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Sealed storage, away from moisture
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture) |
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| 溶解性数据 |
In Vitro:;
H2O : 25 mg/mL (19.06 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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| 参考文献 |
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