Melittin TFA(Synonyms: 蜂毒肽三氟乙酸盐；蜂毒素三氟乙酸盐)

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Melittin TFA;(Synonyms: 蜂毒肽三氟乙酸盐；蜂毒素三氟乙酸盐) 纯度: 99.56%

Melittin TFA 是一种PLA2激活剂，可刺激低分子量 PLA2 的活性，而不会提高高分子量 PLA2 的活性。

Melittin TFAamp;;(Synonyms: 蜂毒肽三氟乙酸盐；蜂毒素三氟乙酸盐)

Melittin TFA Chemical Structure

规格 价格 是否有货 数量
5 mg ￥2000 In-stock
10 mg ￥3500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Melittin TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Melittin TFA is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2[1][2].

IC50 Target

PLA2[1]
体外研究
(In Vitro)

Melittin, an immunologically related PLA2 stimulating peptide from bee venom, increases the activity of the high molecular weight enzyme[1]. Melittin is a cytotoxic peptide from bee venom. Melittin exhibits toxicity against both A2780CR and A2780 cells, with IC50 values of 4.5 and 6.8 μg/mL, respectively. Melittin has natural anti-bacterial, anti-viral, and anti-inflammatory properties. It has also been shown to have diverse anticancer effects in several different cancer cell lines including those of gastric, breast, ovarian, liver, prostate, cervical, and lung origins. The mechanisms by which Melittin, an amphipathic haemolytic peptide, exerts its potential anticancer effects include inhibition of cell proliferation, induction of apoptosis, and direct necrosis. Melittin can also prevent EGF-induced cell invasion through its inhibition of the PI3K/Akt/mTOR signaling pathway, but this is primarily related to breast cancer cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2960.48

Formula

C132H230F3N39O33
Sequence

Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
Sequence Shortening

GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
中文名称

蜂毒肽三氟乙酸盐；蜂毒素三氟乙酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light, stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)
溶解性数据
In Vitro:;

H2O : ≥ 50 mg/mL (16.89 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.3378 mL 1.6889 mL 3.3778 mL
5 mM 0.0676 mL 0.3378 mL 0.6756 mL
10 mM 0.0338 mL 0.1689 mL 0.3378 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Steiner MR, et al. Responses of purified phospholipases A2 to phospholipase A2 activating protein (PLAP) and Melittin. Biochim Biophys Acta. 1993 Feb 10;1166(1):124-30.

    [2]. Alonezi S, et al. Metabolomic Profiling of the Effects of Melittin on Cisplatin Resistant and Cisplatin Sensitive Ovarian Cancer Cells Using Mass Spectrometry and Biolog Microarray Technology. Metabolites. 2016 Oct 13;6(4). pii: E35.