TP508 TFA; 纯度: 99.79%
TP508 TFA 是一种 23 个氨基酸的非蛋白水解凝血酶肽,代表凝血酶分子受体结合结构域的一部分。TP508 TFA 可激活内皮 NO synthase (eNOS) 并刺激人内皮细胞中 NO 的产生。TP508 TFA 通过激活内皮细胞和干细胞以使血管再生和组织再生。
TP508 TFA Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥3500 | In-stock | |
10 mg | ¥5500 | In-stock | |
50 mg | ¥16500 | In-stock | |
100 mg | ; | 询价 | ; |
200 mg | ; | 询价 | ; |
* Please select Quantity before adding items.
TP508 TFA 相关产品
•相关化合物库:
- Drug Repurposing Compound Library Plus
- Clinical Compound Library Plus
- Bioactive Compound Library Plus
- Peptide Library
生物活性 |
TP508 TFA is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 TFA activates endothelial cells and stem cells to revascularize and regenerate tissues[1][2]. |
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体外研究 (In Vitro) |
TP508 (50 μg/mL; 24 hours; HCAEC) treatment reverses radiation-induced endothelial dysfunction (ED) and loss of NO signaling by attenuating the downregulation of eNOS expression. TP508 treatment is able to stimulate NO production in the irradiated cells[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[1]
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体内研究 (In Vivo) |
TP508 (10 mg/kg; intravenous injection; male CD-1 mice) treatment mitigates radiation-induced endothelial cell damage, also significantly increases survival of CD-1 mice when injected 24 h after 8.5 Gy exposure[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
2426.46 |
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Formula |
C99H147N28F3O38S |
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Sequence |
Ala-Gly-Tyr-Lys-Pro-Asp-Glu-Gly-Lys-Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val |
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Sequence Shortening |
AGYKPDEGKRGDACEGDSGGPFV |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:;
H2O : 50 mg/mL (20.61 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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