SiliaBond^® Cyano (Si-CN) can be used both in normal and reversed-phase chromatography as its polarity marks the separation between the polar and non-polar phases. SiliaBond Cyano is the least retentive polar sorbent in normal phase chromatography and the least retentive of the non-polar sorbents in reversed-phase chromatography. This sorbent is particularly useful when dealing with extremes in the polarity scale since it reduces the retention time and help improving peak shapes.