Yuanhuacine(Synonyms: Gnidilatidin)

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Yuanhuacine (Synonyms: Gnidilatidin)

Yuanhuacine (Gnidilatidin)，一种来自 Daphne genkwa 的达芙烷二萜，具有广泛的抗肿瘤活性。Yuanhuacine 是一种具有口服活性的的 DNA 损伤剂。

Yuanhuacine(Synonyms: Gnidilatidin)

Yuanhuacine Chemical Structure

CAS No. : 60195-70-2

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生物活性

Yuanhuacine (Gnidilatidin), a daphnane diterpenoid from the flowers of Daphne genkwa with extensive anti-tumor activity. Yuanhuacine is a DNA-damaging agent with orally active[1][2].

分子量

648.74

Formula

C37H44O10
CAS 号

60195-70-2
中文名称

芫花酯甲
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Ji In Kang, et al. Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells. PLoS One. 2015 Dec 11;10(12):e0144368.

    [2]. Ruowen Zhang, et al. The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade. J Biol Chem. 2014 Mar 7;289(10):6394-403.