上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。
Taraxerol 纯度: ≥99.0%
Taraxerol 是从蒲公英中分离出来的，具有抗炎和抗癌作用。Taraxerol 通过抑制 NF-κB 信号通路来减轻急性炎症。Taraxerol 诱导细胞凋亡 (apoptosis)。
Taraxerol Chemical Structure
CAS No. : 127-22-0
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 1 mg | ￥1000 | In-stock | |
| 5 mg | ￥2500 | In-stock | |
| 10 mg | ￥4200 | In-stock | |
| 50 mg | 询价 | ||
| 100 mg | 询价 |
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Taraxerol 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- Immunology/Inflammation Compound Library
- NF-κB Signaling Compound Library
- Stem Cell Signaling Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- Anti-Aging Compound Library
- Antioxidants Compound Library
- Differentiation Inducing Compound Library
- Lipid Compound Library
- Oxygen Sensing Compound Library
- Medicine Food Homology Compound Library
- Terpenoids Library
- Pyroptosis Compound Library
- Traditional Chinese Medicine Monomer Library
- Anti-Breast Cancer Compound Library
- Anti-Pancreatic Cancer Compound Library
- Anti-Blood Cancer Compound Library
- Anti-Obesity Compound Library
- Transcription Factor Targeted Library
- Food-Sourced Compound Library
- Anti-Liver Cancer Compound Library
| 生物活性 |
Taraxerol is isolated from Abroma augusta L, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis[1][2]. |
IC50 & Target |
IC50: apoptosis[1] |
|---|---|
| 体外研究 (In Vitro) |
Taraxerol (0-100 μM; 24 or 48 hours)significantly reduces cell viability to 95% (20 μM), 89.8% (40 μM), 82.6 % (60 μM), 72.9 % (80 μM), and 63.6% (100 μM).And this compound has cell viability of 90.7% at a concentration of 20 μM and 53.6% at the 100 μM concentration at 48 hours in Hela cells[1]. Taraxerol (80 μM; 24 or 48 hours) induces Hela cells apoptosis and cell death in a dose-dependent manner.Taraxerol can induce a significant apoptosis of cells by annexin V/ PI double staining, significant increase in both the early (24.2%) and late (16.2%) stages of apoptotic cells compared with the control group at the early (6.5%) and late (0.5%) stages[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
| 体内研究 (In Vivo) |
Taraxerol (5 and 10mg/kg; i.p.) attenuates carrageenan induced paw edema 2h onward. The effect of taraxerol at the dose of 5mg/kg is found to be significant (p<0.05) only after 4h of carrageenan treatment[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
426.72 |
| Formula |
C30H50O |
| CAS 号 |
127-22-0 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| 参考文献 |
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