上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。
Hederacolchiside A1 (Synonyms: 革叶常春藤皂苷 A1) 纯度: 99.69%
Hederacolchiside A1 是从白头翁中分离的,通过调节 PI3K/Akt/mTOR 信号通路诱导凋亡,从而抑制肿瘤细胞的增殖。Hederacolchiside A1 具有抗血吸虫病活性,影响体内和体外的寄生虫生存力。
Hederacolchiside A1 Chemical Structure
CAS No. : 106577-39-3
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥2020 | In-stock | |
10 mg | ¥3430 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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Hederacolchiside A1 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Anti-Infection Compound Library
- Apoptosis Compound Library
- Kinase Inhibitor Library
- PI3K/Akt/mTOR Compound Library
- Stem Cell Signaling Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- Autophagy Compound Library
- Anti-Aging Compound Library
- Antioxidants Compound Library
- Glycoside Compound Library
- Oxygen Sensing Compound Library
- Terpenoids Library
- Glycolysis Compound Library
- Cytoskeleton Compound Library
- Glutamine Metabolism Compound Library
- Anti-Breast Cancer Compound Library
- Anti-Pancreatic Cancer Compound Library
- Antiparasitic Compound library
- Anti-Cancer Metabolism Compound Library
- Angiogenesis Related Compound Library
- Glucose Metabolism Compound Library
生物活性 |
Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
897.10 |
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Formula |
C47H76O16 |
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CAS 号 |
106577-39-3 |
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中文名称 |
革叶常春藤皂苷 A1 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (111.47 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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