Ganoderic acid DM(Synonyms: 灵芝酸 DM)

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上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Ganoderic acid DM (Synonyms: 灵芝酸 DM) 纯度: 99.65%

Ganoderic acid DM 是可从 Ganoderma lucidum 分离得到的一个天然三萜，可诱导人乳腺癌细胞的 DNA 损伤、G1 细胞周期阻滞和凋亡。Ganoderic acid DM 还是破骨形成的特异性抑制剂。

Ganoderic acid DM(Synonyms: 灵芝酸 DM)

Ganoderic acid DM Chemical Structure

CAS No. : 173075-45-1

规格 价格 是否有货 数量
1 mg ￥3840 In-stock
5 mg ￥11600 In-stock
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50 mg   询价  

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Ganoderic acid DM 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis[1][2].

体外研究
(In Vitro)

Ganoderic acid DM (GADM) effectively inhibits cell proliferation and colony formation in MCF-7 human breast cancer cells, which was much stronger than that of MDA-MB-231 breast cancer cells[1].
Ganoderic acid DM especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1). Ganoderic acid DM markedly suppressed the expression of cathepsin K and TRAP mRNA[2].
Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MCF-7 and MDA-MB-231 cells.
Concentration: 0-100 μM.
Incubation Time: 48 h.
Result: Decreased the cell viability in breast cancer cells.

Cell Viability Assay[2]

Cell Line: RAW-D cells.
Concentration: 0-100 μg/mL.
Incubation Time: 0-100 μg/mL.
Result: Clearly suppressed osteoclastogenesis from the RAW 264 cell D-clone.

分子量

468.67

Formula

C30H44O4
CAS 号

173075-45-1
中文名称

灵芝酸 DM
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Guo-Sheng Wu, et al. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia. 2012 Mar;83(2):408-14.

    [2]. Ichiko Miyamoto, et al. Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum. Eur J Pharmacol. 2009 Jan 5;602(1):1-7.

    [3]. Junbo Xia, et al. Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity. Chem Biol Interact. 2020 Jan 25;316:108932.