5,8-Epidioxyergosta-6,9(11),22-trien-3-ol(Synonyms: 9,11-Dehydroergosterol peroxide; 9(11)-DHEP)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (Synonyms: 9,11-Dehydroergosterol peroxide; 9(11)-DHEP)

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide)，一种来自药用蘑菇的重要甾体，对几种肿瘤类型具有抗肿瘤活性。5,8-Epidioxyergosta-6,9(11),22-trien-3-ol 通过诱导 CDKN1A 表达抑制 HT29 细胞生长，从而导致细胞周期停滞和凋亡。

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol(Synonyms: 9,11-Dehydroergosterol peroxide; 9(11)-DHEP)

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol Chemical Structure

CAS No. : 86363-50-0

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生物活性

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis[1][2].

IC50 & Target[1]

Microbial Metabolite

 

体外研究
(In Vitro)

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide) is an effective inhibitor of HL60 leukemia cell growth and apoptosis-inducer[1].
Apoptosis induced by 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl‑1 dependent[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

426.63

Formula

C28H42O3
CAS 号

86363-50-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kobori M, Yoshida M, Ohnishi-Kameyama M, Takei T, Shinmoto H. 5alpha,8alpha-Epidioxy-22E-ergosta-6,9(11),22-trien-3beta-ol from an edible mushroom suppresses growth of HL60 leukemia and HT29 colon adenocarcinoma cells. Biol Pharm Bull. 2006;29(4):755-759.

    [2]. Zheng L, et al. Apoptosis induced by 9,11 dehydroergosterol peroxide from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl 1 dependent. Mol Med Rep. 2018;18(1):938-944.