Nigranoic acid

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上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Nigranoic acid 

Nigranoic acid 是五味子中分离得到的一种三萜类化合物。Nigranoic acid 能抑制 HIV-1 逆转录酶。在脑缺血再灌注动物模型中，Nigranoic acid 通过 PARP/AIF 信号通路保护大脑。

Nigranoic acid

Nigranoic acid Chemical Structure

CAS No. : 39111-07-4

规格 价格 是否有货
5 mg ￥6500 询问价格 & 货期

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生物活性

Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model[1][2].

IC50 & Target

HIV-1 reverse transcriptase
体内研究
(In Vivo)

Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation[2].
Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague–Dawley rats (200-300 g), ischemia–reperfusion model[2]
Dosage: 1 mg/kg
Administration: Intragastric; 6 hours and 2 hours before brain ischemia
Result: Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.

分子量

470.68

Formula

C30H46O4
CAS 号

39111-07-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sun HD, et al. Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase. J Nat Prod. 1996 May;59(5):525-7.

    [2]. Feng T, et al. Protective effects of nigranoic acid on cerebral ischemia-reperfusion injury and its mechanism involving apoptotic signaling pathway. Cell Biochem Biophys. 2015 Jan;71(1):345-51.