上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。
Bilobalide (Synonyms: 白果内酯; (-)-Bilobalide) 纯度: ≥98.0%
Bilobalide 是银杏叶中的的一种倍半萜三内酯成分,抑制 NMDA 诱导的胆碱流出,IC50 值为 2.3 µM。Bilobalide 通过激活 SH-SY5Y 细胞中的 PI3K/Akt 通路来防止细胞凋亡 (apoptosis)。对神经元发挥保护和营养作用。
Bilobalide Chemical Structure
CAS No. : 33570-04-6
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥500 | In-stock | |
10 mg | ¥369 | In-stock | |
50 mg | ¥1548 | In-stock | |
100 mg | ¥2727 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
Bilobalide 相关产品
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生物活性 |
Bilobalide, a sesquiterpene trilactone constituent of Ginkgo biloba, inhibits the NMDA-induced efflux of choline with an IC50 value of 2.3 µM. Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells. Exerts protective and trophic effects on neurons[1][2]. |
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IC50 & Target |
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体外研究 (In Vitro) |
Bilobalide (1-100 µM) completely suppresses the NMDA-evoked release of choline in a concentration-dependent manner with IC50 value of 2.3 µM[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis
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体内研究 (In Vivo) |
Bilobalide (20 mg/kg) completely suppresses the NMDA-induced release of choline in vivo while basal choline levels were not significantly affected. NMDA causes a release of choline in vivo when infused into the hippocampus of freely moving rats by retrograde dialysis. Bilobalide (20 mg/kg i.p.) completely inhibits the effect induced by NMDA[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
326.30 |
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Formula |
C15H18O8 |
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CAS 号 |
33570-04-6 |
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中文名称 |
白果内酯 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 100 mg/mL (306.47 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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