Malvidin-3-O-arabinoside chloride

发表于由

天然产物 黄酮类 Flavonoids

Malvidin-3-O-arabinoside chloride 

Malvidin-3-O-arabinoside chloride 通过刺激 Ampk 介导的自噬 (autophagy)，改善氨基甲酸乙酯诱导的氧化损伤。

Malvidin-3-O-arabinoside chloride

Malvidin-3-O-arabinoside chloride Chemical Structure

CAS No. : 28500-04-1

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy[1].

体外研究
(In Vitro)

Malvidin-3-O-arabinoside chloride (M3A chloride, 50-400 μM) pretreatment remarkably upregulates LAMP-1 expression, which indicates elevated lysosomal mass. M3A also successfully restores lysosomal acidity and subsequently strengthenes lysosomal functions. M3A stimulates phosphorylation of AMP-activated protein kinase (AMPK), a master regulator of autophagy[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Autophagy Assay[1]

Cell Line: Caco-2 cell line.
Concentration: 50, 100, 200 and 400 μM.
Incubation Time: 24 h (then treated with or without 10 μM chloroquine (CQ) for another 1 h).
Result: Notably inhibited excess ROS generation.
200 μM and 400 μM M3A pretreatment significantly enhanced 14% and 16% of GSH level.
Enhanced autophagy flux.
Significantly up-regulate the LC3-II/LC3-I ratio.

分子量

498.86

Formula

C22H23ClO11
CAS 号

28500-04-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yuting Li, et al. Malvidin-3-O-arabinoside ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy. Food Funct. 2020 Dec 1;11(12):10317-10328.