2-Hydroxychalcone

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天然产物 黄酮类 Flavonoids

2-Hydroxychalcone 

2-hydroxychalcone 是一种天然黄酮，是一种抗氧化剂，抑制脂质过氧化。2-hydroxychalcone 通过下调 Bcl-2 诱导凋亡。2-Hydroxychalcone 可抑制NF-kB 的激活。

2-Hydroxychalcone

2-Hydroxychalcone Chemical Structure

CAS No. : 644-78-0

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生物活性

2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].

体外研究
(In Vitro)

2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells[1].
2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

224.25

Formula

C15H12O2
CAS 号

644-78-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72.

    [2]. B Madan, et al. 2′-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34.

    [3]. BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.