Hamaudol

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天然产物 黄酮类 Flavonoids

Hamaudol 

Hamaudol 是从 Saposhnikovia divaricata 中分离出的一种色酮。Hamaudol 对环加氧酶 (COX)-1 和 COX-2 的活性具有明显的抑制能力，其 IC50 值分别为 0.30、0.57 mM，并且具有有效抗炎作用，可用于缓解疼痛的研究。

Hamaudol

Hamaudol Chemical Structure

CAS No. : 735-46-6

规格 价格 是否有货
5 mg ￥3360 询问价格 & 货期
10 mg ￥5710 询问价格 & 货期

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生物活性

Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2].

IC50 & Target

COX-1

0.3 mM (IC50)

COX-2

0.57 mM (IC50)

体内研究
(In Vivo)

Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

276.28

Formula

C15H16O5
CAS 号

735-46-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Okuyama E, et al. Analgesic components of saposhnikovia root (Saposhnikovia divaricata). Chem Pharm Bull (Tokyo). 2001 Feb;49(2):154-60.

    [2]. Mingshan Zheng, et al. The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity. Korean Journal of Medicinal Crop Science, 2005, 13(2).