Isoastilbin(Synonyms: 异落新妇苷)

发表于由

天然产物 黄酮类 Flavonoids

Isoastilbin (Synonyms: 异落新妇苷)

Isoastilbin，Rhizoma Smilacis glabrae 和 Astragalus membranaceus 中的一种二氢黄酮醇糖苷化合物。Isoastilbin 抑制葡萄糖基转移酶 (GTase) 的 IC50 值为 54.3 μg/mL，还抑制酪氨酸酶 (tyrosinase) 活性。Isoastilbin 具有神经保护，抗氧化，抗微生物和抗凋亡的特性，并可用于阿尔茨海默氏病的研究。

Isoastilbin(Synonyms: 异落新妇苷)

Isoastilbin Chemical Structure

CAS No. : 54081-48-0

规格 价格 是否有货
1 mg ￥2000 询问价格 & 货期
5 mg ￥5000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research[1][21][3].

IC50 & Target

IC50: 54.3 μg/mL (Glucosyltransferase (GTase)[2]
分子量

450.39

Formula

C21H22O11
CAS 号

54081-48-0
中文名称

异落新妇苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hong Yu, et al. Protective Roles of Isoastilbin Against Alz heimer’s Disease via Nrf2-mediated Antioxidation and anti‑apoptosis. Int J Mol Med. 2019 Mar;43(3):1406-1416.

    [2]. Harlinda Kuspradini, et al. Antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of taxifolin and some flavanonol rhamnosides from kempas (Koompassia malaccensis) extracts. J. Wood Sci., 2009, 55(4):308-13.

    [3]. Batubara, Irmanida, et al. Anti-acne and Tyrosinase Inhibition Properties of Taxifolin and Some Flavanonol Rhamnosides from Kempas. Wood Research Journal ,2010, 1(1):45-9.