Negletein(Synonyms: 黄芩素-7-甲醚; 5,6-Dihydroxy-7-methoxyflavone)

发表于由

天然产物 黄酮类 Flavonoids

Negletein (Synonyms: 黄芩素-7-甲醚; 5,6-Dihydroxy-7-methoxyflavone)

Negletein 是一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突向外生长。Negletein 通过抑制 TNF-α 和 IL-1β 表现出抗炎活性，其 IC50 值分别为 16.4 和 10.8 μM。

Negletein(Synonyms: 黄芩素-7-甲醚; 5,6-Dihydroxy-7-methoxyflavone)

Negletein Chemical Structure

CAS No. : 29550-13-8

规格 价格 是否有货
5 mg ￥3360 询问价格 & 货期
10 mg ￥5710 询问价格 & 货期

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生物活性

Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 and 10.8 μM, respectively[1].

IC50 & Target[1]

TNF-α

16.4 nM (IC50)

IL-1β

10.8 nM (IC50)

分子量

284.26

Formula

C16H12O5
CAS 号

29550-13-8
中文名称

黄芩素-7-甲醚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Phan CW, et al. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Biofactors. 2016 Nov 12;42(6):591-599.

    [2]. Singh B, et al. Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.Nat Prod Res. 2013;27(23):2227-30.