Quercetagetin(Synonyms: 6-Hydroxyquercetin)

发表于由

天然产物 黄酮类 Flavonoids

Quercetagetin (Synonyms: 6-Hydroxyquercetin) 纯度: 99.24%

Quercetagetin (6-Hydroxyquercetin) 是一种类黄酮。Quercetagetin 是一种中等强度和选择性的，细胞渗透性的 pim-1 激酶抑制，IC50 为 0.34 μM。具有抗炎和抗肿瘤活性。

Quercetagetin(Synonyms: 6-Hydroxyquercetin)

Quercetagetin Chemical Structure

CAS No. : 90-18-6

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3190 In-stock
5 mg ￥2900 In-stock
10 mg ￥4900 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Quercetagetin 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Epigenetics Compound Library
  • Immunology/Inflammation Compound Library
  • JAK/STAT Compound Library
  • Kinase Inhibitor Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library
  • Anti-Pancreatic Cancer Compound Library
  • Food-Sourced Compound Library
  • Targeted Diversity Library

生物活性

Quercetagetin (6-Hydroxyquercetin) is a flavonoid[1]. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM)[2]. Anti-inflammatory and anticancer properties.

IC50 & Target[2]

PIM1

0.34 μM (IC50)

PIM2

3.45 μM (IC50)

RSK2

2.82 μM (IC50)

PKA

21.2 μM (IC50)

体外研究
(In Vitro)

Quercetagetin also inhibits PIM2, PKA, and RSK2 with IC50s of 3.45, 21.2, and 2.82 µM, respectively[2].
Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: RWPE2 prostate cancer cells
Concentration: 0.1, 1, 10, and 100 μM
Incubation Time: 72 hours
Result: Inhibited growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM.

体内研究
(In Vivo)

Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SKH-1 hairless mice model[3]
Dosage: 4 or 20 nmol
Administration: Topical application; 28 weeks
Result: Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model.

分子量

318.24

Formula

C15H10O8
CAS 号

90-18-6
中文名称

栎草亭；六羟黄酮；六羟基黄酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 125 mg/mL (392.79 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1423 mL 15.7114 mL 31.4228 mL
5 mM 0.6285 mL 3.1423 mL 6.2846 mL
10 mM 0.3142 mL 1.5711 mL 3.1423 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.54 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.54 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Yang X, et al. Isolation and identification of an antioxidant flavonoid compound from citrus-processing by-product. J Sci Food Agric. 2011 Aug 15;91(10):1925-7.

    [2]. Holder S, et al. Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol Cancer Ther. 2007 Jan;6(1):163-72.

    [3]. Baek S, et al. Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. J Mol Biol. 2013 Jan 23;425(2):411-23.