天然产物 黄酮类 Flavonoids
Licochalcone C (Synonyms: 甘草查尔酮C) 纯度: 99.55%
Licochalcone C 能够抑制 α-葡萄糖苷酶 (α-glucosidase),其对 α-葡萄糖苷酶和蛋白酪氨酸磷酸酶 1B 的 IC50 值分别为 <100 nM 和 92.43 μM。
Licochalcone C Chemical Structure
CAS No. : 144506-14-9
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥3650 | In-stock | |
5 mg | ¥4900 | In-stock | |
10 mg | ¥8500 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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Licochalcone C 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Metabolism/Protease Compound Library
- Natural Product Library
- Traditional Chinese Medicine Monomer Library
- Flavonoids Library
- Anti-Obesity Compound Library
- Glucose Metabolism Compound Library
生物活性 |
Licochalcone C could inhibit α-glucosidase, with IC50s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively. |
IC50 & Target |
IC50: <100 nm (α-glucosidase), 92.43 μm (ptp1b)[1]. |
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体外研究 (In Vitro) |
Licochalcone C could inhibit α- glucosidase, with IC50s of <100 nm and 92.43 μm for α- glucosidase ptp1b, respectively[1]. It is also indicated that Licochalcone C induces T24 cell apoptosis in a concentration‑dependent manner. Licochalcone C treatment reduces the levels of the anti‑apoptotic mRNAs (Bcl-2, Bcl-w and Bcl-XL) and increases expression of the pro-apoptotic mRNAs (Bax and Bim). The Bcl-2 family inhibitor (ABT-737) reduces apoptosis induced by licochalcone C in T24 cells[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
338.40 |
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Formula |
C21H22O4 |
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CAS 号 |
144506-14-9 |
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中文名称 |
甘草查尔酮C |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:
DMSO : 33.33 mg/mL (98.49 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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