7,3′,4′-Tri-O-methylluteolin(Synonyms: 木犀草素-7,3′,4′-三甲醚; 5-Hydroxy-3′,4′,7-trimethoxyflavone)

天然产物 黄酮类 Flavonoids

7,3′,4′-Tri-O-methylluteolin (Synonyms: 木犀草素-7,3′,4′-三甲醚; 5-Hydroxy-3′,4′,7-trimethoxyflavone) 纯度: 99.28%

7,3′,4′-Tri-O-methylluteolin (5-Hydroxy-3′,4′,7-trimethoxyflavone) 是一种类黄酮化合物,通过抑制炎症介质、NO、PGE2 和促炎细胞因子的释放,在 LPS 诱导的巨噬细胞系中具有强大的抗炎作用。7,3′,4′-Tri-O-methylluteolin 显著降低诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。

7,3

7,3′,4′-Tri-O-methylluteolin Chemical Structure

CAS No. : 29080-58-8

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7,3′,4′-Tri-O-methylluteolin 相关产品

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生物活性

7,3′,4′-Tri-O-methylluteolin (5-Hydroxy-3′,4′,7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3′,4′-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2[1].

IC50 & Target[1]

TNF-α

 

IL-6

 

IL-1β

 

COX-2

 

分子量

328.32

Formula

C18H16O6

CAS 号

29080-58-8

中文名称

木犀草素-7,3′,4′-三甲醚;3’4’7-三甲氧基-5-羟基黄酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 20 mg/mL (60.92 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0458 mL 15.2290 mL 30.4581 mL
5 mM 0.6092 mL 3.0458 mL 6.0916 mL
10 mM 0.3046 mL 1.5229 mL 3.0458 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2 mg/mL (6.09 mM); Suspended solution; Need ultrasonic

    此方案可获得 2 mg/mL (6.09 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 20.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Sudha, A, et al. Protective effect of 5-hydroxy-3′,4′,7-trimethoxyflavone against inflammation induced by lipopolysaccharide in RAW 264.7 macrophage: in vitro study and in silico validation. Medicinal Chemistry Research, 2016,25(9), 1754–1767.