天然产物 黄酮类 Flavonoids
Kushenol A (Synonyms: Leachianone E)
Kushenol A (Leachianone E) 从苦参根中分离出来的。Kushenol A 是一种非竞争性酪氨酸酶 (tyrosinase) 抑制剂，可阻止 L-tyrosinase 转化为 L-DOPA，IC50 和 Ki 值分别为 1.1 μM 和 0.4 μM。Kushenol A 是一种类黄酮抗氧化剂，对 α-葡萄糖苷酶 (alpha-glucosidase) (IC50: 45 μM; Ki: 6.8 μM) 和 β-淀粉酶 (beta-amylase) 具有抑制作用。Kushenol A 被认为是化妆品针对皮肤美白和衰老的潜在酶抑制剂。
Kushenol A Chemical Structure
CAS No. : 99217-63-7
| 规格 | 价格 | 是否有货 | |
|---|---|---|---|
| 5 mg | ￥8500 | 询问价格 & 货期 | |
| 10 mg | ￥15000 | 询问价格 & 货期 | |
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Kushenol A 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Metabolism/Protease Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- Phenols Library
- Traditional Chinese Medicine Monomer Library
- Flavonoids Library
- Anti-Lung Cancer Compound Library
- Anti-Obesity Compound Library
- Glucose Metabolism Compound Library
| 生物活性 |
Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC50 and Kivalues of 1.1 μM and 0.4 μM, respectively[1]. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase[2]. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1]. |
IC50 & Target |
IC50: 1.1 μM (tyrosinase); 45 μM (alpha-glucosidase)[1][2] |
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| 体外研究 (In Vitro) |
Kushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC50 value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM[1].Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC50 values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC50 value of 57.2 μg/ml for BEAS-2B cells[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[3]
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| 分子量 |
408.49 |
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| Formula |
C25H28O5 |
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| CAS 号 |
99217-63-7 |
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| 中文名称 |
苦参新醇A |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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| 参考文献 |
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