Irisolidone(Synonyms: 尼泊尔鸢尾异黄酮)

发表于由

天然产物 黄酮类 Flavonoids

Irisolidone (Synonyms: 尼泊尔鸢尾异黄酮) 纯度: 99.66%

Irisolidone 是葛根花中的主要的异黄酮。Irisolidone 具有较强的保肝活性。Irisolidone 对阴离子通道 VRAC 具有高效阻断作用 (IC50=9.8 μM)。

Irisolidone(Synonyms: 尼泊尔鸢尾异黄酮)

Irisolidone Chemical Structure

CAS No. : 2345-17-7

规格 价格 是否有货 数量
1 mg ￥1300 In-stock
5 mg ￥2950 In-stock
10 mg ￥4480 In-stock
50 mg   询价  
100 mg   询价  

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Irisolidone 相关产品

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生物活性

Irisolidone is a major isoflavone found in Pueraria lobata flowers. Irisolidone exhibits potent hepatoprotective activity. Irisolidone shows the high efficacy for volume-regulated anion channels (VRAC) blockade (IC50=9.8 μM)[1][2][3].

体外研究
(In Vitro)

Irisolidone, an isoflavone metabolite, represses JC virus gene expression via inhibition of Sp1 binding in human glial cells[1].
Irisolidone can inhibit endothelial cell proliferation[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

314.29

Formula

C17H14O6
CAS 号

2345-17-7
中文名称

尼泊尔鸢尾异黄酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Kim SY, et al. Irisolidone, an isoflavone metabolite, represses JC virus gene expression via inhibition of Sp1 binding in human glial cells. Biochem Biophys Res Commun. 2006 May 26;344(1):3-8.

    [2]. Zhang G, et al. Pharmacokinetics of irisolidone and its main metabolites in rat plasma determined by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Nov 15;1005:23-9.

    [3]. Xue Y, et al. Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation. Pflugers Arch. 2018 Oct;470(10):1473-1483.