Physcion(Synonyms: 大黄素甲醚; Parietin; Rheochrysidin)

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天然产物醌类Quinones

Physcion (Synonyms: 大黄素甲醚; Parietin; Rheochrysidin) 纯度: 99.10%

Physcion (Parietin) 是从中药大黄中得到的蒽醌类物质，为 6-磷酸葡萄糖酸脱氢酶 (6-phosphogluconate dehydrogenase) 抑制剂，IC50 和 Kd 值分别为 38.5 μM 和 26.0 μM。Physcion (Parietin) 具有通便、保肝、抗炎、抗菌、抗增殖、抗肿瘤作用。

Physcion(Synonyms: 大黄素甲醚; Parietin; Rheochrysidin)

Physcion Chemical Structure

CAS No. : 521-61-9

规格 价格 是否有货 数量
10 mg ￥500 In-stock
25 mg ￥1000 In-stock
50 mg ￥1750 In-stock
100 mg ￥3000 In-stock
200 mg   询价  
500 mg   询价  

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Physcion 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2].

IC50 & Target

IC50: 38.5 μM (6-phosphogluconate dehydrogenase)[1]
Kd: 26.0 μM (6-phosphogluconate dehydrogenase)[1]
分子量

284.26

Formula

C16H12O5
CAS 号

521-61-9
中文名称

大黄素甲醚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

THF : 2.5 mg/mL (8.79 mM; ultrasonic and warming and heat to 60°C)

DMF : 1 mg/mL (3.52 mM; Need ultrasonic)

Acetone : < 1 mg/mL (insoluble)

Ethanol : < 1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96.

    [2]. Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640.