天然产物醌类Quinones
Aclacinomycin A hydrochloride (Synonyms: 盐酸阿柔比星; Aclarubicin hydrochloride) 纯度: 95.16%
Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子,是第一个发现对 20S 蛋白酶体 (20S proteasome) 的 CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效蒽环类化疗试剂用于血癌和实体肿瘤的相关研究。
Aclacinomycin A hydrochloride Chemical Structure
CAS No. : 75443-99-1
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥4479 | In-stock | |
5 mg | ¥2800 | In-stock | |
10 mg | ¥4800 | In-stock | |
25 mg | ¥9800 | In-stock | |
50 mg | ¥16000 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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Aclacinomycin A hydrochloride 相关产品
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生物活性 |
Aclacinomycin A hydrochloride (Aclarubicin hydrochloride), a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome[1]. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II[2]. An effective anthracycline chemotherapeutic agent for hematologic cancers and solid tumors[3]. |
IC50 & Target |
20S proteasome[1]. |
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体外研究 (In Vitro) |
Aclacinomycin A could efficiently enter living cells and emit fluorescence in situ. Aclacinomycin A (10 μM for 15 min) is sufficient for clear detection of fluorescence in most of the cultured cells. Aclacinomycin A treatment (10 μM Acla for 15 min) results in approximately 20% dead (or nearly dead) cells[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Aclacinomycin A is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD50 (76.5 mg/kg) is about twice the iv LD50 (35.6 mg/kg) in mice[4. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
848.33 |
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Formula |
C42H54ClNO15 |
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CAS 号 |
75443-99-1 |
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中文名称 |
盐酸阿柔比星 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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溶解性数据 |
In Vitro:
DMSO : ≥ 125 mg/mL (147.35 mM) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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