Pyrroloquinoline quinone disodium salt(Synonyms: 吡咯喹啉醌二钠盐; PQQ disodium salt; Methoxatin disodium salt)

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天然产物醌类Quinones

Pyrroloquinoline quinone disodium salt (Synonyms: 吡咯喹啉醌二钠盐; PQQ disodium salt; Methoxatin disodium salt) 纯度: ≥98.0%

Pyrroloquinoline quinone disodium salt 是氧化还原辅助因子，一种阴离子型氧化还原循环原醌。Pyrroloquinoline quinone disodium salt 最初是从嗜甲基细菌的培养物中分离的，也存在于哺乳动物的组织。Pyrroloquinoline quinone disodium salt 是哺乳动物的必需营养素，对免疫功能很重要。

Pyrroloquinoline quinone disodium salt(Synonyms: 吡咯喹啉醌二钠盐; PQQ disodium salt; Methoxatin disodium salt)

Pyrroloquinoline quinone disodium salt Chemical Structure

CAS No. : 122628-50-6

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Pyrroloquinoline quinone disodium salt 相关产品

•相关化合物库:

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  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Human Endogenous Metabolite Compound Library
  • Microbial Metabolite Library
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生物活性

Pyrroloquinoline quinone disodium salt, a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone disodium salt is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone disodium salt is an essential nutrient for mammals and is important for immune function[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Mouse pups born to and nursing from Pyrroloquinoline quinone disodium salt-deprived dams have a compromised immune response as well as alopecia, a hunched posture, and a susceptibility to aortic aneurysms[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

374.17

Formula

C14H4N2Na2O8
CAS 号

122628-50-6
中文名称

吡咯喹啉醌二钠盐；吡咯并喹啉苯醌钠盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 1.25 mg/mL (3.34 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6726 mL 13.3629 mL 26.7258 mL
5 mM — — —
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 0.5% CMC-Na/saline water

    Solubility: 5 mg/mL (13.36 mM); Suspended solution; Need ultrasonic

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Moog RS, et al. Evidence for methoxatin (pyrroloquinolinequinone) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8435-9.

    [2]. Bishop A, et al. Methoxatin (PQQ) in guinea-pig neutrophils. Free Radic Biol Med. 1994 Oct;17(4):311-20.