天然产物 天然产物苯丙素类 Phenylpropanoids
Angelicin (Synonyms: 异补骨脂素; Isopsoralen) 纯度: 99.86%
异补骨脂素 (Angelicin) 是一种天然的三环芳烃化合物,结构上跟补骨脂素有关,具有抗癌、抗炎、抗病毒等活性。具有细胞毒性,IC50:49.56 μM;抑制MHV-68,IC50: 5.39 μg/ml (28.95 μM)。
Angelicin Chemical Structure
CAS No. : 523-50-2
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥880 | In-stock | |
5 mg | ¥800 | In-stock | |
10 mg | ¥1200 | In-stock | |
50 mg | ¥4200 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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Angelicin 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Anti-Infection Compound Library
- Apoptosis Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- Antiviral Compound Library
- Lipid Compound Library
- Traditional Chinese Medicine Monomer Library
- FDA Approved & Pharmacopeial Drug Library
- Food-Sourced Compound Library
生物活性 |
Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity. IC50 value: 49.56 μM (cellular cytotoxicity); 5.39 μg/ml (28.95 μM) (against MHV-68) Target: In vitro: In human SH-SY5Y neuroblastoma cells, angelicin increased cellular cytotoxicity in a dose- and time-dependent manner with IC50 of 49.56 μM at 48 h of incubation. Angelicin dose-dependently downregulated the expression of anti-apoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1; Angelicin-induced apoptosis is mediated primarily through the intrinsic caspase-mediated pathway[1]. Angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells [2]. Angelicin was potentially advantageous to prevent inflammatory diseases by inhibiting NF-κB and MAPK pathways [3]. In vivo: |
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分子量 |
186.16 |
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Formula |
C11H6O3 |
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CAS 号 |
523-50-2 |
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中文名称 |
异补骨脂素;异香柠檬烯;异佛手柑内酯;异补骨酯素;当归素 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 33.33 mg/mL (179.04 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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