天然产物 天然产物苯丙素类 Phenylpropanoids
Hypophyllanthin 纯度: 98.40%
Hypophyllanthin 是 Phyllanthus spp 中主要的一种木质素,具有很强的抗炎活性。Hypophyllanthin 能直接抑制 P-gp 的活性,而不干扰 MRP2 活性。
Hypophyllanthin Chemical Structure
CAS No. : 33676-00-5
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥1250 | In-stock | |
5 mg | ¥3150 | In-stock | |
10 mg | 询价 | ||
50 mg | 询价 |
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Hypophyllanthin 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Immunology/Inflammation Compound Library
- Membrane Transporter/Ion Channel Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- Pyroptosis Compound Library
生物活性 |
Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2]. |
IC50 & Target |
P-gp[2] |
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体外研究 (In Vitro) |
Hypophyllanthin down-regulates COX-2, TNF-α, and IL-1β gene expressions in U937 macrophages by interfering with the activation of NF-κB, MAPKs, and Akt[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
430.49 |
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Formula |
C24H30O7 |
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CAS 号 |
33676-00-5 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:
DMSO : 33.33 mg/mL (77.42 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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