Yatein(Synonyms: 亚太因)

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

Yatein (Synonyms: 亚太因)

Yatein 是从 A. chilensis 中提取的木质素，具有抗增殖活性。Yatein 能通过中断立早基因的表达，抑制单纯疱疹病毒 1 型 (HSV-1) 的复制。

Yatein(Synonyms: 亚太因)

Yatein Chemical Structure

CAS No. : 40456-50-6

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Yatein is a lignan isolated from A. chilensis, with antiproliferative activity[1]. Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression[2].

IC50 & Target

HSV-1[2]
体外研究
(In Vitro)

Yatein induces cell-cycle arrest at G2/M phase (5 μM; 24 hours) and enhances G2/M phase-related protein expression (5 μM; 6-12 hours) in human lung adenocarcinoma A549 and CL1-5 cells[3].
Yatein (5 μM; 6-12 hours) induces DNA damage through activation of the ATM/ATR pathway in human A549 and CL1-5 cells[3].
Yatein (5 μM; 6 hours) affects microtubule dynamics by inhibiting tubulin polymerization[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[3]

Cell Line: A549 cells, CL1-5 cells
Concentration: 1.25 μM , 2.5 μM , 5 μM
Incubation Time: 24 hours
Result: Induced cell-cycle arrest at G2/M phase in both cell lines.

Western Blot Analysis[3]

Cell Line: A549 cells, CL1-5 cells
Concentration: 5 μM
Incubation Time: 6 hours, 12 hours
Result: Upregulated the expression of cyclin B1, but not Cdc2 and Cdc25c, induced Cdc2 phosphorylation.

体内研究
(In Vivo)

Yatein (20 mg/kg; i.p.; five times per week; for 42 days) exhibits in vivo antitumor effects in a human lung adenocarcinoma xenograft mouse model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NOD/SCID mice (6-8 weeks), with A549 cells xenograft[3]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection, five times per week, for 42 days
Result: Significantly slowed tumor growth and moderately increased both cyclin B1 expression and Cdc2 phosphorylation.

分子量

400.42

Formula

C22H24O7
CAS 号

40456-50-6
中文名称

亚太因
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Donoso-Fierro C, et al. Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: cytological studies and chemical investigations. Pharm Biol. 2015 Mar;53(3):378-85.

    [2]. Kuo YC, et al. Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression. Antiviral Res. 2006 Jul;70(3):112-20.

    [3]. Shang-Tse Ho, et al. Molecular Mechanisms Underlying Yatein-Induced Cell-Cycle Arrest and Microtubule Destabilization in Human Lung Adenocarcinoma Cells. Cancers (Basel). 2019 Sep; 11(9): 1384.