Methyl (E)-cinnamate(Synonyms: Methyl (E)-3-phenylpropenoate)

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天然产物 天然产物苯丙素类 Phenylpropanoids

Methyl (E)-cinnamate (Synonyms: Methyl (E)-3-phenylpropenoate)

Methyl (E)-cinnamate (EMC) 作为一种植物化学成分分离自 Alpinia katsumadai Hayata，是一种天然香料化合物，具有抗炎作用。Methyl (E)-cinnamate (EMC) 在食品和日用品工业中应用广泛。

Methyl (E)-cinnamate(Synonyms: Methyl (E)-3-phenylpropenoate)

Methyl (E)-cinnamate Chemical Structure

CAS No. : 1754-62-7

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生物活性

Methyl (E)-cinnamate (EMC), a phytochemical constituent isolated from Alpinia katsumadai Hayata, is a natural flavor compound with anti-inflammatory properties. Methyl (E)-cinnamate is widely used in the food and commodity industry[1].

体外研究
(In Vitro)

Methyl (E)-cinnamate (0~30 μM; 24 hours; MC3T3-E1 cells) significantly increases the cleaved forms of poly (ADP-ribose) polymerase (PARP) and caspase-3, while it decreases the expression levels of Survivin and Bcl-2, and significantly increases TUNEL-positive and DAPI-stained cells[1].
Methyl (E)-cinnamate (0~30 μM;7 days; MC3T3-E1 cells) suppresses the osteoblast differentiation[1].
Methyl (E)-cinnamate (1~100 μM; 24 and 48 hours; MC3T3-E1 cells) decreases cell survival and induces morphological changes. EMC decreases MAPKs signaling and cell migration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MC3T3-E1 cells
Concentration: 0~30 μM
Incubation Time: 24 hours
Result: Significantly increased the cleaved forms of poly (ADP-ribose) polymerase (PARP) and caspase-3, while it decreased the expression levels of Survivin and Bcl-2.

Apoptosis Analysis[1]

Cell Line: MC3T3-E1 cells
Concentration: 0~30 μM
Incubation Time: 24 hours
Result: Significantly increased TUNEL-positive and DAPI-stained cells.

Cell Differentiation Assay[1]

Cell Line: MC3T3-E1 cells
Concentration: 0~30 μM
Incubation Time: 7 days
Result: Suppressed the osteoblast differentiation.

分子量

162.19

Formula

C10H10O2
CAS 号

1754-62-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Park KR, et al. A Phytochemical Constituent, (E)-Methyl-Cinnamate Isolated from Alpinia katsumadai Hayata Suppresses Cell Survival, Migration, and Differentiation in Pre-Osteoblasts. Int J Mol Sci. 2020;21(10):3700. Published 2020 May 24.