天然产物 糖类和糖苷 Saccharides and Glycosides
Protodioscin (Synonyms: 原薯蓣皂苷) 纯度: ≥98.0%
Protodioscin 是山药根茎中主要的甾体皂苷类化合物,具有抗血脂、抗肿瘤,保护心血管等多种功效。
Protodioscin Chemical Structure
CAS No. : 55056-80-9
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥1143 | In-stock | |
5 mg | ¥600 | In-stock | |
10 mg | ¥990 | In-stock | |
25 mg | ¥2200 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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Protodioscin 相关产品
•相关化合物库:
- Natural Product Library Plus
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- Metabolism/Protease Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- Human Endogenous Metabolite Compound Library
- Glycoside Compound Library
- Lipid Compound Library
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- Pyroptosis Compound Library
- Traditional Chinese Medicine Monomer Library
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生物活性 |
Protodioscin, a major steroidal saponin in dioscoreae rhizome, has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties. |
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IC50 & Target |
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体内研究 (In Vivo) |
Protodioscin (5 and 10 mg/kg) significantly improves glucose intolerance and reduced the levels of serum UA, BUN, Cr, TC and TG. Protodioscin significantly reduces renal concentrations of IL-1β, IL-6 and TNF-α by inhibiting the activation of nuclear factor-κB, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase[1]. Protodioscin ameliorates the death rate, inhibits the increase in neurological deficit scores and infarct volume, and reduces the apoptotic nerve cells induced by MCAO in rats. Protodioscin attenuates the change of relevant apoptins, suppresses the release of pro-inflammatory cytokines in serum and reverses the protein expression of NF-κB (in nucleus and cytoplasm) and IκBα (in cytoplasm) induced by MCAO in rats[2]. Protodioscin (0.5 mg/kg, i.p.) increases the coagulation time by appr 50 % as compared to that of high-fat diet control rats. Protodioscin possesses a promising effect in lowering the blood levels of both lipoproteins, especially LDL, thus resulting in a high ratio of HDL/LDL[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
1049.20 |
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Formula |
C51H84O22 |
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CAS 号 |
55056-80-9 |
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中文名称 |
原薯蓣皂苷 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
H2O : 50 mg/mL (47.66 mM; Need ultrasonic) DMSO : 50 mg/mL (47.66 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Animal Administration [1] |
After habituation for 7 days, the animals are randomly divided into either the control (n=10) or experimental (n=40) group. Mice in the control group receive drinking water and standard chow, while the experimental group receive 30% (w/v) fructose in drinking water and standard chow for 12 weeks. After 6 weeks, mice receiving high-dose fructose are divided into four subgroups: fructose group (treated with CMC-Na in a matched volume), allopurinol (Allo) group (administered 5 mg/kg allopurinol hydrochloride), protodioscin-5 (Pdio-5) group (administered 5 mg/kg protodioscin) and protodioscin-10 (Pdio-10) group (administered 10 mg/kg protodioscin). Dose of protodioscin is selected according to other reports and the clinical adult dose of DR. According to the pharmacopoeia of China, the dose of DR for human is 30 g/day. Equivalently, the calculated dose of DR based on respective body surface areas for rats is 2.6 g/kg/day. The average content of protodioscin in DR is 0.183%, and so the dose of protodioscin for rats is 4.76 mg/kg/day. Therefore, the 5 mg/kg/day is as low dose, and 10 mg/kg/day is as high dose in this study. All drugs are administered orally once daily between 9:00 and 11:00 a.m., continuously for 6 weeks. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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