天然产物 糖类和糖苷 Saccharides and Glycosides
Ophiopogonin D (Synonyms: 麦冬皂苷D) 纯度: 98.59%
Ophiopogonin D 是从麦冬 (Ophiopogon japonicus) 的块茎中分离的,是一种罕见的天然存在的 C29 甾体糖苷。Ophiopogonin D 是 CYP2J3 诱导剂,其通过增加人脐静脉内皮细胞 (HUVECs) 中 CYP2J2/EETs 和 PPARα 的表达,显着抑制 Ang II 诱导的 NF-κB 核转位,IκBα 下调,细胞内 Ca2+ 过载和促炎细胞因子的激活。Ophiopogonin D 已被用于炎症和心血管疾病的相关研究。
Ophiopogonin D Chemical Structure
CAS No. : 945619-74-9
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5 mg | ¥1750 | In-stock | |
10 mg | ¥2350 | 询价 | |
25 mg | ¥3950 | 询价 | |
50 mg | 询价 | ||
100 mg | 询价 |
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Ophiopogonin D 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Cell Cycle/DNA Damage Compound Library
- Immunology/Inflammation Compound Library
- Membrane Transporter/Ion Channel Compound Library
- Neuronal Signaling Compound Library
- NF-κB Signaling Compound Library
- Stem Cell Signaling Compound Library
- Natural Product Library
- Anti-Aging Compound Library
- Antioxidants Compound Library
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- Lipid Metabolism Compound Library
- Anti-Liver Cancer Compound Library
生物活性 |
Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside[1]. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years[2]. |
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IC50 & Target |
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分子量 |
855.02 |
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Formula |
C44H70O16 |
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CAS 号 |
945619-74-9 |
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中文名称 |
麦冬皂苷D |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (116.96 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 MCE 网站选购。
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参考文献 |
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