天然产物 糖类和糖苷 Saccharides and Glycosides
Methyl protodioscin;(Synonyms: NSC-698790; Smilax saponin B) 纯度: ge;98.0%
甲基原薯蓣皂甙(Methyl protodioscin)是一种具有抗肿瘤活性甾二糖苷,能诱导细胞周期阻滞。
Methyl protodioscin Chemical Structure
CAS No. : 54522-52-0
规格 | 价格 | 是否有货 | 数量 |
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10;mM;*;1 mL in DMSO | ¥4678 | In-stock | |
5 mg | ¥2200 | In-stock | |
10 mg | ¥4000 | In-stock | |
50 mg | ¥12000 | In-stock | |
100 mg | 询价 |
* Please select Quantity before adding items.
Methyl protodioscin 相关产品
bull;相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- Glycoside Compound Library
- Lipid Compound Library
- Medicine Food Homology Compound Library
- Traditional Chinese Medicine Monomer Library
生物活性 |
Methyl protodioscin(NSC-698790) is a furostanol bisglycoside with antitumor properties; shows to reduce proliferation, cause cell cycle arrest. IC50 value: Target: in vitro: MPD showed growth inhibitory effects in A549 cells in a dose- and time-dependent manner. The significant G2/M cell cycle arrest and apoptotic effect were also seen in A549 cells treated with MPD. MPD-induced apoptosis was accompanied by a significant reduction of mitochondrial membrane potential, release of mitochondrial cytochrome c to cytosol, activation of caspase-3, downregulation of Bcl-2, p-Bad, and upregulation of Bax [1]. In THP-1 macrophages, MPD increases levels of ABCA1 mRNA and protein in dose- and time-dependent manners, and apoA-1-mediated cholesterol efflux. MPD also decreases the gene expressions of HMGCR, FAS and ACC for cholesterol and fatty acid synthesis [2]. |
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分子量 |
1063.23 |
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Formula |
C52H86O22 |
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CAS 号 |
54522-52-0 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4deg;C, protect from light *In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:;
DMSO : 140 mg/mL (131.67 mM; Need ultrasonic) H2O : 25 mg/mL (23.51 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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