Polyphyllin G(Synonyms: 重楼皂苷G)

天然产物 糖类和糖苷 Saccharides and Glycosides

Polyphyllin G;(Synonyms: 重楼皂苷G)

Polyphyllin G 重楼皂苷G 是从 Paris yunnanensis 的根茎中分离出来的,具有抗菌和抗癌活性。 Polyphyllin G 以最小的抑制浓度 (MIC) 阻止革兰氏阳性和革兰氏阴性细菌的生长。Polyphyllin G 诱导凋亡 (apoptosis) 依赖于 caspase-8,-3 和 -9 的激活,诱导自噬 (autophagy)。

Polyphyllin G(Synonyms: 重楼皂苷G)

Polyphyllin G Chemical Structure

CAS No. : 76296-75-8

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生物活性

Polyphyllin G is isolated from the rhizomes of Paris yunnanensis, with antimicrobial and anticancer activity. Polyphyllin G prevents the growth of both Gram-positive and Gram-negative bacteria with minimum inhibitory concentrations (MICs)[1]. Polyphyllin G induces apoptosis dependent on the activations of caspase-8, -3, and -9, induces autophagy[2].

分子量

1049.20

Formula

C51H84O22

CAS 号

76296-75-8

中文名称

重楼皂苷G

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Cai X, et al. Polyphyllin G exhibits antimicrobial activity and exerts anticancer effects on human oral cancer OECM-1 cells by triggering G2/M cell cycle arrest by inactivating cdc25C-cdc2. Arch Biochem Biophys. 2018 Apr 15;644:93-99.

    [2]. Hsieh MJ, et al. Polyphyllin G induces apoptosis and autophagy cell death in human oral cancer cells. Phytomedicine. 2016 Dec 1;23(13):1545-1554.