天然产物 糖类和糖苷 Saccharides and Glycosides
Gypenoside XVII;(Synonyms: Gynosaponin S) 纯度: 99.63%
Gypenoside XVII 是一种属于绞股蓝皂甙类的新型植物雌激素,可激活雌激素受体 (estrogen receptors)。
Gypenoside XVII Chemical Structure
CAS No. : 80321-69-3
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5 mg | ¥1000 | In-stock | |
10 mg | ¥1600 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
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Gypenoside XVII 相关产品
bull;相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Metabolism/Protease Compound Library
- Natural Product Library
- Human Endogenous Metabolite Compound Library
- Glycoside Compound Library
- Anti-Cardiovascular Disease Compound Library
- Traditional Chinese Medicine Monomer Library
- Food-Sourced Compound Library
生物活性 |
Gypenoside XVII, a novel phytoestrogen belonging to the gypenosides, can activate estrogen receptors. |
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IC50 Target |
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体外研究 (In Vitro) |
The ability of Gypenoside XVII (GP-17) to prevent Ox-LDL-induced cytotoxicity is detected by cell viability assays. Gypenoside XVII does not demonstrate any cytotoxicity in HUVECs. Gypenoside XVII can protect HUVECs against Ox-LDL-induced apoptosis. Gypenoside XVII dose-dependently mitigates the toxic effect of Ox-LDL on HUVEC viability. The viability of HUVECs is significantly higher than that of other groups at 50 μg/mL Gypenoside XVII [1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Body weights are measured as physical measures of hormone bioactivity. Mean body weights are significantly higher in every group compared to that of the control, but there is no significant difference in body weight between the different treatments during the 10-week feeding. The mouse plasma lipid levels are also measured at the end of 10 weeks of a high-fat diet. Circulating levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are significantly increased in the treated groups of ApoE-/- mice compared with those of the C57BL/6J control group; Gypenoside XVII (GP-17) and Probucol treatment substantially decreases both of these parameters relative to those of the ApoE-/- model group[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
947.15 |
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Formula |
C48H82O18 |
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CAS 号 |
80321-69-3 |
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中文名称 |
七叶胆苷 XVII;绞股蓝皂苷 XVII |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4deg;C, protect from light *In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:;
DMSO : ≥ 100 mg/mL (105.58 mM) H2O : 41.67 mg/mL (44.00 mM; Need ultrasonic) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Cell Assay [1] |
For the establishment of an Ox-LDL-induced apoptosis model and measurement of Gypenoside XVII’s protective effect, the HUVECs are seeded in 96-well plates at a density of 105 cells per mL and grown for 24 h. Then, the HUVECs are pretreated with Gypenoside XVII (6.25, 12, 25, 50, 100 μg/mL) for 12 h in serum-free endothelial cell basal medium, followed by incubation with Ox-LDL (100 μg/mL, 24 h) which does not have Gypenoside XVII. After 24 h, the treated HUVECs are incubated with 5 mg/mL MTT in fresh medium for an additional 4 h. Absorbance is measured at 570 nm using a plate reader[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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Animal Administration [1] |
Mice[1] MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
参考文献 |
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