Nothofagin

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天然产物 糖类和糖苷 Saccharides and Glycosides

Nothofagin;

Nothofagin 是一种二氢查尔酮，是从如意宝 (Aspalathus linearis) 中分离得到的。Nothofagin 通过阻断钙 (calcium) 内流来下调 NF-κB 的转运。Nothofagin 具有抗氧化活性，可改善各种炎症反应，例如脓毒症反应和血管炎症。

Nothofagin

Nothofagin Chemical Structure

CAS No. : 11023-94-2

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5 mg ￥12500 询问价格 货期

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生物活性

Nothofagin, a dihydrochalcone, is isolated from rooibos (Aspalathus linearis)[1]. Nothofagin downregulates NF-κB translocation through blocking calcium influx. Nothofagin has antioxidant activity and ameliorates various inflammatory responses such as the septic response and vascular inflammation[2].

体外研究
(In Vitro)

Nothofagin pre-treatment (0.1, 1, 10 μM) decreases the level of histamine release in RBL-2H3 and RPMCs cells. The production of cytokines are downregulated bynothofagin pre-treatment Nothofagin (TNF-α: 1-10 μM; IL-4: 0.1-10 μM, IL-6: 1-10 μM)[1].
Pre-treatment of DNPHSA-stimulated RBL-2H3 with Nothofagin (10 μM) markedly suppresses the phosphorylation of Lyn, Syk, and Akt[1].
Nothofagin (30 μM; for 6 hours) results in inhibited formation of LPS-induced (100 ng/mL; 4 hours) paracellular gaps with the formation of dense F-actin rings in HUVECs[2].
Nothofagin suppresses IgE-mediated mast cell degranulation both in vitro and in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Nothofagin (1 mg/kg; orally; once a day; for 7 days) significantly increases the urinary volume of both normotensive (NTR) and spontaneously hypertensive rats (SHR)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar normotensive and spontaneously hypertensive rats (3-4 months old) [3]
Dosage: 1 mg/kg
Administration: Orally; once a day; for 7 days
Result: Significantly increased the urinary volume of both NTR and SHR.

分子量

436.41

Formula

C21H24O10
CAS 号

11023-94-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wonhwa Lee, et al. Anti-inflammatory Effects of Aspalathin and Nothofagin From Rooibos (Aspalathus Linearis) In Vitro and In Vivo. Inflammation. 2015 Aug;38(4):1502-16.

    [2]. Byeong-Cheol Kang, et al. Nothofagin Suppresses Mast Cell-Mediated Allergic Inflammation. Chem Biol Interact. 2019 Jan 25;298:1-7.

    [3]. Camila Leandra Bueno de Almeida, et al. Prolonged Diuretic and Saluretic Effect of Nothofagin Isolated From Leandra Dasytricha (A. Gray) Cogn. Leaves in Normotensive and Hypertensive Rats: Role of Antioxidant System and Renal Protection. Chem Biol Interact. 2018 Jan 5;279:227-233.