Glychionide A(Synonyms: 去甲汉黄芩素-7-O-葡萄糖醛酸苷)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Glychionide A;(Synonyms: 去甲汉黄芩素-7-O-葡萄糖醛酸苷)

Glychionide A 是一种黄酮苷，存在于 Glychirriza glabra 的根中。Glychionide A 促进 PANC-1 胰腺癌细胞的凋亡和自噬。Glychionide A 可用于癌症的研究。

Glychionide A(Synonyms: 去甲汉黄芩素-7-O-葡萄糖醛酸苷)

Glychionide A Chemical Structure

CAS No. : 119152-50-0

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer[1][2].

体外研究
(In Vitro)

Glychionide A (3.12-100 μM) significantly inhibits the proliferation of the PANC-1 pancreatic cancer cells, with an IC50 of 14 μM[1].
Glychionide A (7-28 μM) induces both autophagy and apoptosis in pancreatic cancer cells[1].
Glychionide A (7-28 μM) causes G2/M arrest of PANC-1 pancreatic cancer cells[1].
Glychionide A (7-28 μM) causes generation of ROS in PANC-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

446.36

Formula

C21H18O11
CAS 号

119152-50-0
中文名称

去甲汉黄芩素-7-O-葡萄糖醛酸苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li JR, et, al. Two new compounds from Glycyrrhiza glabra. J Asian Nat Prod Res. 2005 Aug;7(4):677-80.

    [2]. Yu L, et, al. Antitumor Effects of Glychionide-A Flavonoid in Human Pancreatic Carcinoma Cells Are Mediated by Activation of Apoptotic and Autophagic Pathways, Cell Cycle Arrest, and Disruption of Mitochondrial Membrane Potential. Med Sci Monit. 2019 Feb 3;25:962-969.