天然产物 糖类和糖苷 Saccharides and Glycosides
Miquelianin;(Synonyms: Quercetin 3-O-glucuronide; Quercetin 3-glucuronide) 纯度: 99.83%
Miquelianin (Quercetin 3-O-glucuronide)是槲皮素和一种天然类黄酮的代谢产物。
Miquelianin Chemical Structure
CAS No. : 22688-79-5
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | ; | Apply now | ; |
10;mM;*;1 mL in DMSO | ¥990 | In-stock | |
5 mg | ¥900 | In-stock | |
10 mg | ¥1400 | In-stock | |
25 mg | ¥3000 | In-stock | |
50 mg | ¥4800 | In-stock | |
100 mg | ¥7800 | In-stock | |
200 mg | ; | 询价 | ; |
500 mg | ; | 询价 | ; |
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Miquelianin 相关产品
bull;相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Metabolism/Protease Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- CNS-Penetrant Compound Library
- Human Endogenous Metabolite Compound Library
- Glycoside Compound Library
- Phenols Library
- Traditional Chinese Medicine Monomer Library
- Flavonoids Library
- Anti-Breast Cancer Compound Library
生物活性 |
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. |
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IC50 Target |
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体外研究 (In Vitro) |
Miquelianin shows an antioxidant effect in human plasma. At 50 μM, miquelianin suppresses the consumption of the three antioxidants lycopene, β-carotene and α-tocopherol significantly[1]. In vitro studies indicate that miquelianin is able to reach the central nervous system from the small intestine[2]. Miquelianin significantly reduces the generation of β-amyloid (Aβ) peptides by primary neuron cultures generated from the Tg2576 AD mouse model. It is also capable of interfering with the initial protein-protein interaction of Aβ1–40 and Aβ1–42 that is necessary for the formation of neurotoxic oligomeric Aβ species[3]. Treatment with 0.1 μM miquelianin suppresses ROS generation, cAMP and RAS activation, phosphorylation of ERK1/2 and the expression of HMOX1, MMP2, and MMP9 genes. Miquelianin suppresses invasion of MDA-MB-231 breast cancer cells and MMP-9 induction, and inhibits the binding of [3H]-NA to b2-AR. Miquelianin may function to suppress invasion of breast cancer cells by controlling b2-adrenergic signaling, and may be a dietary chemopreventive factor for stress-related breast cancer[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Miquelianin treatment, compared to vehicle-control treatment, significantly improves AD-type deficits in hippocampal formation basal synaptic transmission and long-term potentiation[3]. A flavonoid fraction obtained from a crude extract of Hypericum perforatum (St. John’s wort) is remarkably active in the forced swimming test. Miquelianin is one of the compound separated from the fraction[5]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
478.36 |
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Formula |
C21H18O13 |
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CAS 号 |
22688-79-5 |
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中文名称 |
槲皮素-3-O-葡萄糖醛酸苷 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:;
DMSO : ≥ 30 mg/mL (62.71 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Animal Administration [5] |
Rats: Miquelianin is administered orally using the gavage techniques. The rats are treated with 0.6 mg/kg miquelianin for 12 days. Antidepressant activity is performed using the Forced Swimming Test[5]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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