天然产物 糖类和糖苷 Saccharides and Glycosides
Spiramycin;(Synonyms: 螺旋霉素; Rovamycin) 纯度: 98.56%
Spiramycin (Rovamycin) 是由链霉菌 (Streptomyces ambofaciens) 产生的大环内酯抗生素,具有抗细菌和抗弓形虫的作用,并具有抗寄生虫作用。Spiramycin (Rovamycin) 由 16 个内酯环组成,其上附着三种糖 (mycaminose,forosamine 和 mycarose)。
Spiramycin Chemical Structure
CAS No. : 8025-81-8
规格 | 价格 | 是否有货 | 数量 |
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10;mM;*;1 mL in DMSO | ¥790 | In-stock | |
100 mg | ¥600 | In-stock | |
200 mg | ; | 询价 | ; |
500 mg | ; | 询价 | ; |
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生物活性 |
Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. Spiramycin is composed of a 16-member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached[1][2]. |
IC50 Target |
Bacterial[1] |
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体外研究 (In Vitro) |
Spiramycin (24 hours; 1-1000 μM; T. gondii infected HeLa cells and HeLa cells) treatment reduces the cytotoxicity, and shows anti-Toxoplasma gondii activity, with IC50 values of 189 μM for HeLa cells; and 262 μM for T. gondii-infected HeLa cells[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity Assay[3]
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体内研究 (In Vivo) |
Spiramycin (100 mg/kg; intraperitoneal injection; every day; for 4 days; female KM mice) treatment reduces the number of tachyzoites, and reduces hepatotoxicity and significantly enhances antioxidative effects. Spiramycin treatment also decreases in the degree of granulomatous inflammation in the liver[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
843.05 |
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Formula |
C43H74N2O14 |
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CAS 号 |
8025-81-8 |
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中文名称 |
螺旋霉素 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:;
DMSO : ≥ 100 mg/mL (118.62 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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