Sucralose(Synonyms: 三氯蔗糖; E955; Trichlorosucrose)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Sucralose;(Synonyms: 三氯蔗糖; E955; Trichlorosucrose) 纯度: ge;98.0%

Sucralose (E955; Trichlorosucrose) 是一种无营养的人工甜味剂 (sweetener) 和代糖。Sucralose 可以激活保守神经的禁食响应，从而对啮齿动物产生食欲刺激作用。

Sucralose(Synonyms: 三氯蔗糖; E955; Trichlorosucrose)

Sucralose Chemical Structure

CAS No. : 56038-13-2

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ￥550 In-stock
100 mg ￥500 In-stock
500 mg ￥1000 In-stock
1 g ; 询价 ;
5 g ; 询价 ;

* Please select Quantity before adding items.

Sucralose 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Anti-Cancer Compound Library
  • Clinical Compound Library
  • Human Endogenous Metabolite Compound Library
  • Drug Repurposing Compound Library
  • Anti-COVID-19 Compound Library
  • Orally Active Compound Library
  • FDA Approved amp; Pharmacopeial Drug Library
  • Anti-Blood Cancer Compound Library
  • Food Additive Library
  • Inactive Ingredient Library

生物活性

Sucralose (E955; Trichlorosucrose) is a non-nutritive artificial sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents[1][2].

IC50 Target

Human Endogenous Metabolite

;

体内研究
(In Vivo)

The results show that Sucralose induces significant increased incidence of all hematopoietic neoplasias in male mice exposed to 2,000 (p≤0.01), and 16,000 ppm (p≤0.01), with a significant dose-related relationship (p≤0.01). Microscopically, most of the neoplasias among male mice treated with Sucralose at 2,000 to 16,000 ppm are leukemias involving lungs, liver, spleen, lymph nodes, and bone marrow with diffuse permeation of vessels and extensive infiltration of adjacent tissues[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

397.63

Formula

C12H19Cl3O8
CAS 号

56038-13-2
中文名称

三氯蔗糖；蔗糖素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (251.49 mM; Need ultrasonic)

DMSO : 100 mg/mL (251.49 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5149 mL 12.5745 mL 25.1490 mL
5 mM 0.5030 mL 2.5149 mL 5.0298 mL
10 mM 0.2515 mL 1.2575 mL 2.5149 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. M S, et al. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. Int J Occup Environ Health. 2016 Jan;22(1):7-17.

    [2]. Nabanita Kundu, et al. Sucralose promotes accumulation of reactive oxygen species (ROS) and adipogenesis in mesenchymal stromal cells. Stem Cell Res Ther. 2020 Jun 26;11(1):250.
Animal Administration
[1]

Sucralose is pulverized in a standard pelleted diet at concentrations 0, 500, 2,000, 8,000, and 16,000 ppm and is administered to five groups of male (n=117, 114, 90, 66, and 70, respectively) and five groups female (n=102, 105, 60, 65, and 64, respectively) Swiss mice from the 12th day of fetal life until death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. M S, et al. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. Int J Occup Environ Health. 2016 Jan;22(1):7-17.

    [2]. Nabanita Kundu, et al. Sucralose promotes accumulation of reactive oxygen species (ROS) and adipogenesis in mesenchymal stromal cells. Stem Cell Res Ther. 2020 Jun 26;11(1):250.